The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress

Background: Inflammation could be a risk factor for the development of depression and change the outcome of this common chronic-recurrent mental disorder. Aims: This study aimed to investigate if bone marrow mononuclear cell (BMMC) transplantation is effective in restoring sucrose preference in rats...

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Published in:Journal of psychopharmacology (Oxford) 2019-05, Vol.33 (5), p.632-639
Main Authors: do Prado-Lima, Pedro Antônio Schmidt, Onsten, Guilherme Ary, de Oliveira, Gutierre Neves, Brito, Guilherme Camargo, Ghilardi, Isadora Machado, de Souza, Eduardo Vieira, dos Santos, Paula Gabrielli, Salamoni, Simone Denise, Machado, Denise Cantarelli, Duarte, Marta Medeiros Frescura, Barbisan, Fernanda, da Cruz, Ivana Beatrice Mânica, Costa-Ferro, Zaquer Suzana Munhoz, daCosta, Jaderson Costa
Format: Article
Language:English
Subjects:
Amygdala
Antidepressants
Bone marrow
Bone marrow transplantation
Central nervous system
Citalopram
Cortex (frontal)
Cytokines
Deoxyguanosine
Deoxyribonucleic acid
DNA
DNA damage
IL-1β
Inflammation
Interferon
Interleukin 10
Interleukin 6
Mental depression
Risk factors
Serotonin
Serotonin uptake inhibitors
Spleen
Sucrose
Sugar
Transplantation
Tumor necrosis factor-α
γ-Interferon
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Summary:Background: Inflammation could be a risk factor for the development of depression and change the outcome of this common chronic-recurrent mental disorder. Aims: This study aimed to investigate if bone marrow mononuclear cell (BMMC) transplantation is effective in restoring sucrose preference in rats subjected to chronic stress (CS), if it has an anti-inflammatory effect and is able to restore damaged DNA. Methods: The effect of BMMC transplantation was studied in a controlled protocol (compared with a control group and a selective serotonin reuptake inhibitor escitalopram group) involving sucrose preference in CS in rats. Measurements were taken of the amygdala, hippocampus, frontal cortex, and other brain areas, the spleen and blood pro-inflammatory cytokines, namely interleukin-1β, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma, as well as anti-inflammatory cytokine interleukin-10. Finally, 8-hydroxy-2’-deoxyguanosine (a DNA damage marker) was determined. Results: BMMC transplantation was as effective as escitalopram in restoring sucrose preference. It also had an anti-inflammatory effect and slightly improved damaged DNA after one week. Conclusions: These findings suggest administration of BMMC in rats subjected to CS restores sucrose preference, resolves inflammation in both the peripheral and central nervous system, as well as diminishes DNA damage. This effect was similar to that of escitalopram, which is effective in the treatment of depressive patients.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881119841562