Neurophysiological abnormalities in individuals with persistent post-concussion symptoms

Concussion injury results in a rapid onset of transient neurological impairment that can resolve quickly, or sometimes evolve over time, but usually resolve within seven to 10 days. However, a small but noticeable cohort (~10%) of individuals continues to experience persistent lingering effects, par...

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Bibliographic Details
Published in:Neuroscience 2019-06, Vol.408, p.272-281
Main Authors: Pearce, Alan J., Tommerdahl, Mark, King, Doug A.
Format: Article
Language:English
Subjects:
Adult
Brain - physiopathology
Evoked Potentials, Motor - physiology
fatigue
Fatigue - complications
Fatigue - physiopathology
Female
Humans
Male
Middle Aged
Neuropsychological Tests
post concussion symptoms
Post-Concussion Syndrome - complications
Post-Concussion Syndrome - physiopathology
Reaction Time - physiology
self-assessment questionnaire
somatosensory
Surveys and Questionnaires
Transcranial Magnetic Stimulation
vibrotactile
Young Adult
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Summary:Concussion injury results in a rapid onset of transient neurological impairment that can resolve quickly, or sometimes evolve over time, but usually resolve within seven to 10 days. However, a small but noticeable cohort (~10%) of individuals continues to experience persistent lingering effects, particularly fatigue, recognized as post-concussion symptoms (PCS). This study explored neurophysiological mechanisms in people with persistent PCS. Studies involved using self-report post-concussion fatigue scale, transcranial magnetic stimulation (TMS) and somatosensory stimulation in those with diagnosed PCS (n = 20; 36.1 ± 14.0 yr., 4 female; mean time post-concussion 15.4 ± 7.6 months) to fully recovered individuals (n = 20; 33.8 ± 6.6 yr., 2 female; post-concussion 12.9 ± 6.6 months) and healthy controls (n = 20; 37.7 ± 8.0 yr., 3 female). PCS participants demonstrated a significantly higher self-report fatigue (score: PCS 20.2 [95% CI 17.4–22.9], Recovered 6.2 [3.1–9.3], Control 2.75 [0.6–4.8]). PCS participants showed a worsening of reaction time (F2,57 = 4.214; p = 0.020) and increased reaction time variability (F2,57 = 5.505; p = 0.007). Somatosensory differences were observed for amplitude discrimination (F2,57 = 5.166; p = 0.009), temporal order judgment (F2,57 = 4.606; p = 0.014) and duration discrimination (F2,57 = 6.081; p = 0.004). Increased intracortical inhibition in TMS single pulse suprathreshold stimulation (110%: F2,57 = 6.842; p = 0.002; 130%: F2,57 = 4.900; p = 0.011; 150%: F2,57 = 4.638; p = 0.014; 170%: F2,57 = 9.845; p 
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2019.04.019