Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action

Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2019/07/01, Vol.42(7), pp.1134-1139
Main Authors: Imai, Masahiko, Yokoe, Hiromasa, Tsubuki, Masayoshi, Takahashi, Noriko
Format: Article
Language:English
Subjects:
Acids
Antineoplastic Agents - pharmacology
Apoptosis
Breast
Breast cancer
Breast Neoplasms - drug therapy
Caffeic acid
caffeic acid phenethyl ester
Cell Proliferation - drug effects
Cinnamates - pharmacology
Cinnamic acid
Humans
Male
MCF-7 Cells
PC-3 Cells
Prostate cancer
Prostatic Neoplasms - drug therapy
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Summary:Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester (6) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-01002