Chamiside A, a Cytochalasan with a Tricyclic Core Skeleton from the Endophytic Fungus Chaetomium nigricolor F5

Chamiside A (1), a novel cytochalasan with a new 6/6/5-fused tricyclic core skeleton, was isolated from an endophytic fungus, Chaetomium nigricolor F5, harbored in the medicinal plant Mahonia fortunei. Its structure was unambiguously determined by extensive spectroscopic analyses, measurement of sin...

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Bibliographic Details
Published in:Organic letters 2019-05, Vol.21 (9), p.3319-3322
Main Authors: Wang, Hang-Hang, Li, Gang, Qiao, Ya-Nan, Sun, Yong, Peng, Xiao-Ping, Lou, Hong-Xiang
Format: Article
Language:English
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Summary:Chamiside A (1), a novel cytochalasan with a new 6/6/5-fused tricyclic core skeleton, was isolated from an endophytic fungus, Chaetomium nigricolor F5, harbored in the medicinal plant Mahonia fortunei. Its structure was unambiguously determined by extensive spectroscopic analyses, measurement of single-crystal X-ray diffraction, and electronic circular dichroism calculation. A biosynthetic pathway for the unique ring system in 1 was proposed. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b01065