Evidence of higher intramyocellular fat among normal and overweight Indians with prediabetes

The rise in prevalence rates of Type 2 Diabetes among Indians is well recognized. The research focus has been primarily to understand the changes in insulin sensitivity and beta cell dysfunction among Indians with Type 2 Diabetes. However, no data are available on the role of peripheral tissue, in p...

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Published in:European journal of clinical nutrition 2019-10, Vol.73 (10), p.1373-1381
Main Authors: Sucharita, S, Pranathi, R, Correa, M, Keerthana, P, Ramesh, L J, Bantwal, G, Venkatappa, H M, Mahadev, K P, Thomas, T, Bosch, R J, Harridge, S D R, Kurpad, A V
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - pathology
Adult
Beta cells
Biopsy
Body Composition
Body Mass Index
Body weight
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Dual energy X-ray absorptiometry
Glucose
Glucose Tolerance Test
Homeostasis
Humans
India
Insulin
Insulin secretion
Lipids
Lipids - analysis
Male
Methyltestosterone
Muscle Strength
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Musculoskeletal system
Oils & fats
Overweight
Overweight - metabolism
Peptides
Prediabetic State - metabolism
Prediabetic State - pathology
Quadriceps muscle
Secretion
Sensitivity
Skeletal muscle
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Summary:The rise in prevalence rates of Type 2 Diabetes among Indians is well recognized. The research focus has been primarily to understand the changes in insulin sensitivity and beta cell dysfunction among Indians with Type 2 Diabetes. However, no data are available on the role of peripheral tissue, in particular intramyocellular lipid (IMCL) content and its impact on glucose homeostasis among Indians with prediabetes. 28 male subjects (20-40 year) were studied. 13 with prediabetes (BMI ranging from 25.4 ± 2.9 kg/m ) and 15 controls (BMI ranging from 24.6 ± 2.8 kg/m ) were recruited. Body composition by dual energy X-ray absorptiometry (DXA), insulin sensitivity, insulin secretion rates were derived using the minimal model of C-peptide secretion and kinetics rates and skeletal muscle strength of the lower limb (quadriceps) was assessed using Isokinetic dynamometry. From muscle biopsy samples of the vastus lateralis, IMCL fat content (Oil red O staining) was determined. The prediabetes group were older compared to controls (P 
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-019-0402-4