Nonsurviving Patients with Severe Traumatic Brain Injury Have Maintained High Serum sCD40L Levels

Soluble cluster of differentiation 40 ligand (sCD40L) is a member of the tumor necrosis factor family with proinflamatory and procoagulant effects. A previous study found higher serum sCD40L levels at day 1 of traumatic brain injury (TBI) in nonsurviving than surviving patients. Thus the objective o...

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Bibliographic Details
Published in:World neurosurgery 2019-06, Vol.126, p.e1537-e1541
Main Authors: Lorente, Leonardo, Martín, María M., González-Rivero, Agustín F., Ramos, Luis, Argueso, Mónica, Cáceres, Juan J., Solé-Violán, Jordi, Jiménez, Alejandro, Borreguero-León, Juan M., García-Marín, Victor
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Brain Injuries, Traumatic - blood
Brain Injuries, Traumatic - mortality
Brain trauma
CD40 Ligand - blood
Female
Glasgow Coma Scale
Humans
Injury
Male
Middle Aged
Mortality
Patients
Predictive Value of Tests
Prospective Studies
sCD40L
Survival Analysis
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Summary:Soluble cluster of differentiation 40 ligand (sCD40L) is a member of the tumor necrosis factor family with proinflamatory and procoagulant effects. A previous study found higher serum sCD40L levels at day 1 of traumatic brain injury (TBI) in nonsurviving than surviving patients. Thus the objective of this study was to compare serum sCD40L levels during the first week of a severe TBI between surviving and nonsurviving patients and to determine whether it could be used as a mortality predictor biomarker. In this multicenter study severe TBI patients (with Glasgow Coma Scale score
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2019.03.179