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Expression analysis of selected miR‐206 targets from the transforming growth factor‐β signaling pathway in breast cancer
Breast cancer as a molecularly heterogeneous malignancy is associated with dysregulation of several signaling pathways, including transforming growth factor‐β (TGF‐β) signaling. On the other hand, several recent studies have demonstrated the role of microRNAs (miRNAs) in breast cancer pathogenesis....
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Published in: | Journal of cellular biochemistry 2019-08, Vol.120 (8), p.13545-13553 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Breast cancer as a molecularly heterogeneous malignancy is associated with dysregulation of several signaling pathways, including transforming growth factor‐β (TGF‐β) signaling. On the other hand, several recent studies have demonstrated the role of microRNAs (miRNAs) in breast cancer pathogenesis. In the current study, we performed a computerized search to find miR‐206 target genes that are functionally linked to the TGF‐β signaling pathway. We selected LEF1,
Smad2, and
Snail2 genes to assess their expression in 65 breast cancer samples and their adjacent noncancerous tissues (ANCTs) in correlation with expression levels of miR‐206 as well as clinicopathological characteristics of patients. miR‐206 was significantly downregulated in (Estrogen receptor) ER‐positive breast cancer samples compared with their corresponding ANCTs. Association analysis between expression levels of genes and demographic features of patients showed significant association between expressions of
SMAD2 and
LEF1 genes and body mass index (
P values of 0.03 and 0.02, respectively). miR‐206 low‐expression levels were associated with TNM stage, mitotic rate, and lymph node involvement (
P values of 0.02, 0.01, and 0.01 respectively). In addition,
SMAD2 high‐expression levels were associated with HER2 status (
P = 0.02). Consequently, our data highlight the role of TGF‐β signaling dysregulation in the pathogenesis of breast cancer and warrant further evaluation of miRNAs and messenger RNA coding genes in this pathway to facilitate detection of cancer biomarkers and therapeutic targets.
Our data highlight the role of transforming growth factor‐β signaling dysregulation in the pathogenesis of breast cancer and warrant further evaluation of microRNAs and messenger RNA coding genes in this pathway to facilitate detection of cancer biomarkers and therapeutic targets. |
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ISSN: | 0730-2312 1097-4644 |
DOI: | 10.1002/jcb.28629 |