Human Leukocyte Antigen Compatibility and De Novo Donor-Specific Antibodies in Long-term Renal Transplant Patients With Stable Graft Function

De novo donor-specific antibodies (DSA) are associated with antibody-mediated rejection leading to late renal transplant failure. The aim of this study was to evaluate whether HLA compatibility is associated with sensitization along with other risk factors. Eighty-nine stable renal transplant recipi...

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Bibliographic Details
Published in:Transplantation proceedings 2019-03, Vol.51 (2), p.413-415
Main Authors: Kasimatis, E., Fylaktou, A., Karampatakis, T., Schoina, M., Zarras, C., Anastasiou, A., Papachristou, M., Boukla, A., Daoudaki, M., Fouzas, I., Papagianni, A.
Format: Article
Language:English
Subjects:
Adult
Female
Graft Rejection - immunology
Graft Survival - immunology
Histocompatibility - immunology
HLA Antigens - immunology
Humans
Isoantibodies - immunology
Kidney Transplantation
Male
Middle Aged
Tissue Donors
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Summary:De novo donor-specific antibodies (DSA) are associated with antibody-mediated rejection leading to late renal transplant failure. The aim of this study was to evaluate whether HLA compatibility is associated with sensitization along with other risk factors. Eighty-nine stable renal transplant recipients (47 men) were studied. Patients were classified into 2 groups according to HLA compatibility between donor and recipient, group A (1–4/8 matches) and group B (5–8/8 matches). Cold ischemia time (CIT) and delayed graft function (DGF) were recorded along with time with a functional graft. Anti-HLA antibodies were detected using a Luminex single-antigen bead assay and were further classified into DSA and non-DSA. HLA group A consisted of 49 (56%) transplant recipients while 38 (44%) were classified to group B, with functional grafts for 10.9 ± 6.7 and 14.8 ± 8.5 years, respectively (P = .019). Group A patients had more anti-HLA antibodies than group Β (P = .001) and this correlation was retained for DSA patients. De novo anti-HLA were detected in 40 patients; DSA were detected in 19 (21.8%). DSA (+) patients had recorded with functional renal grafts for 11 ± 5 years, compared to 14.4 ± 8.6 years (P = .048) for anti-HLA negative patients. Increased CIT and DGF were associated with anti-HLA antibodies detection but no with DSA. HLA compatibility is probably correlated with DSA in a context of a more general anti-HLA sensitization, and both have a negative effect on long-term renal graft outcome.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2019.01.013