Characterizing and Modeling Bone Formation during Mouse Calvarial Development

The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is n...

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Bibliographic Details
Published in:Physical review letters 2019-02, Vol.122 (4), p.048103-048103, Article 048103
Main Authors: Marghoub, Arsalan, Libby, Joseph, Babbs, Christian, Ventikos, Yiannis, Fagan, Michael J, Moazen, Mehran
Format: Article
Language:English
Subjects:
Algorithms
Animals
Bones
Children
Computer simulation
Edge joints
Mice
Modelling
Models, Biological
Osteogenesis
Skull - diagnostic imaging
Skull - growth & development
Skull - physiology
Sutures
X-Ray Microtomography
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Summary:The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is not well understood. In a series of previous studies, we characterized and modeled radial expansion of normal and craniosynostotic (Crouzon) mice. Here, we describe a new modeling algorithm to simulate bone formation at the sutures in normal and craniosynostotic mice. Our results demonstrate that our modeling approach is capable of predicting the observed ex vivo pattern of bone formation at the sutures in the aforementioned mice. The same approach can be used to model different calvarial reconstruction in children with craniosynostosis to assist in the management of this complex condition.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.122.048103