Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the target systolic blood pressure for optimal outcome is uncertain. We assessed intensive blood pressure lowering compared with guid...

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Published in:	The Lancet (British edition) 2019-03, Vol.393 (10174), p.877-888
Main Authors:	Anderson, Craig S, Arima, Hisatomi, Chen, Guofang, Martins, Sheila O, Silva, Federico, Thang, Nguyen H, Li, Qiang, Martins, Sheila O., Pontes-Neto, Octavio M., Wang, Xia, Simes, R. John, Hirakawa, Yoichiro, Moullaali, Tom J., Carcel, Cheryl, Gordon, Penny, Cao, Yongjun, Winters, Stephen, Zhang, Shihong, Manning, Lisa, Minhas, Jatinder, Malavera, Alejandra, Ivanova, Elizaveta, Armenis, Manuela, Blacklock, Nick, Naidu, Bala, Smith, Phillipa, Kong, Liang, Ebraimo, Ahtasam, Phuong, Do M., Tran, Nguyen T.B., Hoa, Nguyen A., Ray, E., Ng, G., Weiss, G., Titton, N., Castro, R., Fagundes, D., Alves, M., Rivas, R., Herrera, A., Zhou, S., Ping, L., Shi, J., Gong, P., Zhao, H., Li, R., Liu, D., Liang, L., Xia, J., Zhao, N., Huang, W., Zhang, A., Liu, H., Zhang, Y., Li, F., Huang, L., Zheng, R., Liu, J., Zhang, S., Liu, X., Lai, Y., Du, J., Wei, C., Li, W, Zeng, X., Wu, X., Castellanos, J.A., Raj, P.G., Parmar, M., Patel, D., Gorthi, S.P., Prabhu, A., Nair, R., TP, S., Choudhury, N., Duberkar, D., Sacchini, E., Padiglioni, C., Kim, J., Hwang, H.W., Kwon, S.U., Kim, Y.J., Kim, B., Kim, Y.W., Lee, J.J., Chang, H.M., Martínez, A., Lin, Y.J., Huang, Y.C., Dyker, A., Natarajan, I., Qadiri, M.R., Smith, C., James, M., Marsden, T., Price, C., Bergin, A., Le Kim, K., Le Thanh, T. Tran
Format:	Article
Language:	eng
Subjects:	Administration, Intravenous Aged Australia - epidemiology Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Brain Ischemia - drug therapy Brain Ischemia - pathology Brain research Brazil - epidemiology Clinical trials Evidence-based medicine Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use Health Hemorrhage Humans Intracranial Hemorrhages - epidemiology Intravenous administration Male Medical imaging Medical research Middle Aged Patients Practice Guidelines as Topic Pressure reduction Prospective Studies Randomization Regression analysis Republic of Korea - epidemiology Safety Stroke Stroke - drug therapy Thrombolysis Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use Treatment Outcome
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