Boosting Non‐Radiative Decay to Do Useful Work: Development of a Multi‐Modality Theranostic System from an AIEgen

The efficient utilization of energy dissipating from non‐radiative excited‐state decay of fluorophores was only rarely reported. Herein, we demonstrate how to boost the energy generation of non‐radiative decay and use it for cancer theranostics. A novel compound (TFM) was synthesized which possesses...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-04, Vol.58 (17), p.5628-5632
Main Authors: Wang, Dong, Lee, Michelle M. S., Xu, Wenhan, Shan, Guogang, Zheng, Xiaoyan, Kwok, Ryan T. K., Lam, Jacky W. Y., Hu, Xianglong, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
aggregation-induced emission
Cancer
Chemical compounds
Deactivation
Decay
Energy dissipation
Energy utilization
Fluorescence
Fluorophores
Molecular dynamics
molecular dynamics simulations
multi-modality theranostics
Nanoparticles
nonradiative decay
Phototherapy
Photothermal conversion
Precision medicine
Reactive oxygen species
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Summary:The efficient utilization of energy dissipating from non‐radiative excited‐state decay of fluorophores was only rarely reported. Herein, we demonstrate how to boost the energy generation of non‐radiative decay and use it for cancer theranostics. A novel compound (TFM) was synthesized which possesses a rotor‐like twisted structure, strong absorption in the far red/near‐infrared region, and it shows aggregation‐induced emission (AIE). Molecular dynamics simulations reveal that the TFM aggregate is in an amorphous form consisting of disordered molecules in a loose packing state, which allows efficient intramolecular motions, and consequently elevates energy dissipation from the pathway of thermal deactivation. These intrinsic features enable TFM nanoparticles (NPs) to display a high photothermal conversion efficiency (51.2 %), an excellent photoacoustic (PA) effect, and effective reactive oxygen species (ROS) generation. In vivo evaluation shows that the TFM NPs are excellent candidates for PA imaging‐guided phototherapy. No radiation, no problem! A novel AIEgen was synthesized and confirmed to be an excellent platform for elevating energy dissipation from nonradiative decay. This AIEgen has a high photothermal conversion efficiency (51.2 %), an excellent photoacoustic effect and effective reactive oxygen species generation, making it powerful in multi‐modality theranostics for cancer treatment.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201900366