The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review

The pathogenesis underlying cluster headache remains an unresolved issue. Although both the autonomic system and the hypothalamus play a central role, the modality of their involvement remains largely unknown. It is, also, unknown why the duration of the pain attacks is so brief and why their onset...

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Bibliographic Details
Published in:Neurological sciences 2019-05, Vol.40 (Suppl 1), p.39-44
Main Authors: D’Andrea, G., Gucciardi, A., Perini, F., Leon, A.
Format: Article
Language:English
Subjects:
Animals
Arginine
Autonomic nervous system
Autonomic Nervous System - metabolism
Autonomic Nervous System - physiopathology
Cluster Headache - etiology
Cluster Headache - metabolism
Headache
Headaches
Humans
Hypothalamus
Hypothalamus - metabolism
Medicine
Medicine & Public Health
Neurology
Neuromodulation
Neuroradiology
Neurosciences
Neurosurgery
Neurotransmitter Agents - metabolism
Neurotransmitters
Pain
Pain - complications
Pain - metabolism
Pathogenesis
Psychiatry
Review Article
Tryptophan
Tyrosine
Tyrosine - metabolism
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Summary:The pathogenesis underlying cluster headache remains an unresolved issue. Although both the autonomic system and the hypothalamus play a central role, the modality of their involvement remains largely unknown. It is, also, unknown why the duration of the pain attacks is so brief and why their onset and termination are abrupt and extremely painful. This review summarizes the evidence to date accumulated in favor of a possible role of anomalies in the metabolism of tyrosine, tryptophan, and arginine in these unresolved issues.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-019-03768-9