Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis

Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E‐cadherin expression and high‐grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apo...

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Bibliographic Details
Published in:Pathology international 2019-05, Vol.69 (5), p.288-293
Main Authors: Ishii, Akiko, Oishi, Takuma, Kakuda, Yuko, Yasui, Haruna, Kawata, Takuya, Muramatsu, Koji, Takahashi, Kaoru, Sugino, Takashi
Format: Article
Language:English
Subjects:
Aged, 80 and over
apocrine carcinoma
Breast
Breast - pathology
breast carcinoma
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cadherins - metabolism
Carcinoma in Situ - pathology
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - diagnosis
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - pathology
Case reports
Cell membranes
Cytoplasm
E‐cadherin
Female
Humans
Invasiveness
mixed carcinoma
Morphology
Pathogenesis
pleomorphic lobular carcinoma
Sweat Gland Neoplasms - diagnosis
Sweat Gland Neoplasms - metabolism
Sweat Gland Neoplasms - pathology
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Summary:Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E‐cadherin expression and high‐grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is presented. Histologically, the tumor showed two distinct carcinoma components: one was a typical apocrine carcinoma, and the other was a pleomorphic invasive lobular carcinoma. The former showed complete membranous expression of E‐cadherin, whereas the latter aberrantly expressed it not on the cell membrane, but in the cytoplasm. Both components were triple‐negative and strongly positive for GCDFP‐15, suggesting apocrine differentiation. The intraductal component showed only a feature of apocrine ductal carcinoma in situ. This case suggests that apocrine carcinoma could be an origin of PLC.
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.12781