Expression of YY1 in Wilms tumors with favorable histology is a risk factor for adverse outcomes

To investigate the role of the transcription factor YY1 in Wilms tumor (WT). We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2019-04, Vol.15 (11), p.1231-1241
Main Authors: Zapata-Tarres, Marta, Juarez-Villegas, Luis E, Maldonado-Valenzuela, Altagracia, Baay-Guzman, Guillermina J, Lopez-Perez, Tania V, Cabrera-Muñoz, Lourdes, Sadowinski-Pine, Stanislaw, Huerta-Yepez, Sara
Format: Article
Language:English
Subjects:
blastemal component
Cancer therapies
Chemotherapy
Cyclin-dependent kinases
digital pathology
favorable histology
Gene expression
Histology
immunohistochemistry
Kinases
Medical prognosis
Metastasis
Pathology
Pediatrics
poor prognosis factor
Prostate cancer
Protein expression
Proteins
tissue microarray
Transcription factors
triphasic component
Tumors
Wilms tumor
YY1
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Summary:To investigate the role of the transcription factor YY1 in Wilms tumor (WT). We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical and protein expression was determined by digital pathology. YY1 significantly increased in WT patients. In addition, an increase in YY1 expression had a greater risk of adverse outcomes in WT patients with favorable histology. YY1 expression was higher in the blastemal component of tumors, and high nuclear expression positively correlated with metastasis. YY1 may be considered as a metastasis risk factor in WT.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2018-0764