A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid

A lysosome-targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid. More importantly, the real-time tracking of the dynamic movement of lysosomes, as vesicle structures, has been achieved using Lyso-MC.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-02, Vol.55 (18), p.2688-2691
Main Authors: Tan, Hui-Ya, Qiu, Yu-Tai, Sun, Han, Yan, Jin-Wu, Zhang, Lei
Format: Article
Language:English
Subjects:
Fluorescent indicators
Lysosomes
Viscosity
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Description
Summary:A lysosome-targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid. More importantly, the real-time tracking of the dynamic movement of lysosomes, as vesicle structures, has been achieved using Lyso-MC.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00113a