Enhanced recovery versus conventional care in gastric cancer surgery: a meta-analysis of randomized and non-randomized controlled trials

Introduction Enhanced recovery after surgery (ERAS) protocols have been successfully integrated into peri-operative management of different cancer surgeries such as colorectal cancer. Their value for gastric cancer surgery, however, remains uncertain. Methods A search for randomized and observationa...

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Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2019-05, Vol.22 (3), p.423-434
Main Authors: Wee, Ian Jun Yan, Syn, Nicholas Li-Xun, Shabbir, Asim, Kim, Guowei, So, Jimmy B. Y.
Format: Article
Language:English
Subjects:
Abdominal Surgery
C-reactive protein
Cancer Research
Cancer surgery
Clinical trials
Colorectal carcinoma
Gastric cancer
Gastroenterology
Interleukin 6
Laparoscopy
Medicine
Medicine & Public Health
Meta-analysis
Morbidity
Oncology
Patients
Prospero protein
Review Article
Surgery
Surgical Oncology
Tumor necrosis factor-α
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Summary:Introduction Enhanced recovery after surgery (ERAS) protocols have been successfully integrated into peri-operative management of different cancer surgeries such as colorectal cancer. Their value for gastric cancer surgery, however, remains uncertain. Methods A search for randomized and observational studies comparing ERAS versus conventional care in gastric cancer surgery was performed according to PRISMA guidelines. Random-effects meta-analyses with inverse variance weighting were conducted, and quality of included studies was assessed using the Cochrane risk-of-bias tool and Newcastle-Ottawa scale (PROSPERO: CRD42017080888). Results Twenty-three studies involving 2686 patients were included. ERAS was associated with reduced length of hospital stay (WMD—2.47 days, 95% CI − 3.06 to − 1.89, P  
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-019-00937-9