Reliability of calcium–phosphorus (Ca/P) ratio as a new, accurate and inexpensive tool in the diagnosis of some Ca–P disorders

Purpose The serum calcium/phosphorus (Ca/P) ratio is an accurate tool to differentiate patients with primary hyperparathyroidism (PHPT) from healthy subjects. However, other disorders of the Ca–P metabolism might impair the Ca/P ratio, such as hypophosphatemia (HypoP) not PHPT related. The aim of th...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2019-09, Vol.42 (9), p.1041-1049
Main Authors: Madeo, B., De Vincentis, S., Kara, E., Vescini, F., Trenti, T., Guaraldi, G., Rochira, V.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - metabolism
Calcium
Calcium (blood)
Calcium - metabolism
Case-Control Studies
Creatinine
Diagnosis
Endocrinology
Female
Follow-Up Studies
HIV
HIV - isolation & purification
HIV Infections - complications
HIV Infections - metabolism
HIV Infections - virology
Human immunodeficiency virus
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary - complications
Hyperparathyroidism, Primary - diagnosis
Hyperparathyroidism, Primary - metabolism
Hypophosphatemia
Hypophosphatemia - complications
Hypophosphatemia - diagnosis
Hypophosphatemia - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Original Article
Parathyroid
Parathyroid hormone
Phosphorus
Phosphorus - metabolism
Prognosis
Reproducibility of Results
Retrospective Studies
Vitamin D
Young Adult
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Summary:Purpose The serum calcium/phosphorus (Ca/P) ratio is an accurate tool to differentiate patients with primary hyperparathyroidism (PHPT) from healthy subjects. However, other disorders of the Ca–P metabolism might impair the Ca/P ratio, such as hypophosphatemia (HypoP) not PHPT related. The aim of this study is to examine the diagnostic value of Ca/P ratio in the diagnosis of PHPT and HypoP not PHPT related. Methods Single-center, retrospective, case–control study, including 150 patients with PHPT and 306 patients with HypoP, compared with 150 controls. HypoP patients were enrolled among HIV-infected patients by selecting those with Fanconi-like syndrome due to antiretroviral treatment. Parameters which were measured were serum Ca, P, parathyroid hormone (PTH), 25-OH vitamin D, albumin and creatinine). Results The Ca/P ratio was significantly higher in PHPT and HypoP patients, compared to controls ( p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-019-01025-6