Clinical Profile and Outcome of Children with Congenital Obstructive Uropathy

Objectives To study the etiology and clinical profile of congenital obstructive uropathy in children, renal status and growth at diagnosis and at follow-up and to determine the predictors for development of chronic kidney disease (CKD). Methods An observational (retrospective-prospective) study was...

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Bibliographic Details
Published in:Indian journal of pediatrics 2019-04, Vol.86 (4), p.354-359
Main Authors: Tangirala, Susmitha, Bhaskaranand, Nalini, Kini, Pushpa G., Konda, Kalyan Chakravarthy, Gajjala, Sahithi Teja
Format: Article
Language:English
Subjects:
Child, Preschool
Female
Gynecology
Humans
Infant
Male
Medicine
Medicine & Public Health
Original Article
Pediatrics
Sex Factors
Ureteral Obstruction - congenital
Ureteral Obstruction - pathology
Urogenital Abnormalities - pathology
Urogenital Abnormalities - therapy
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Summary:Objectives To study the etiology and clinical profile of congenital obstructive uropathy in children, renal status and growth at diagnosis and at follow-up and to determine the predictors for development of chronic kidney disease (CKD). Methods An observational (retrospective-prospective) study was conducted at a tertiary care hospital in South India from September 2014 through September 2016. Sixty children diagnosed to have congenital obstructive uropathy with a minimum follow-up period of 5 y were included and followed up prospectively for 2 more years during the study period. The data of the children at admission and follow-up was obtained from the medical records and analyzed. Results Congenital uretero-pelvic junction obstruction followed by Posterior urethral valve were the most common etiologies identified. Male preponderance (88.3%) was observed with poor urinary stream being the most common presentation (36.6%). Forty percent of the population had elevated creatinine. Fifteen percent were hypertensive and 25% had growth failure at diagnosis. However, there was a reduction in the number of children with poor estimated glomerular filtration rate (eGFR), hypertension and growth faltering during follow-up. Among the risk factors, hypertension at diagnosis [O.R-12.8 (2.21–74.22) and p value
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-019-02876-w