Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice

•Short-term HFD consumption increases hippocampal β-Amyloid and Tau phosphorylation.•This process is associated with increased inflammatory, ER stress and apoptotic signals.•IL1β and β-Amyloid content increases with HFD in different regions of hippocampus. The consumption of saturated fatty acids is...

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Published in:	Brain, behavior, and immunity behavior, and immunity, 2019-07, Vol.79, p.284-293
Main Authors:	Nakandakari, Susana Castelo Branco Ramos, Muñoz, Vitor Rosetto, Kuga, Gabriel Keine, Gaspar, Rafael Calais, Sant'Ana, Marcella Ramos, Pavan, Isadora Carolina Betim, da Silva, Luiz Guilherme Salvino, Morelli, Ana Paula, Simabuco, Fernando Moreira, da Silva, Adelino Sanchez Ramos, de Moura, Leandro Pereira, Ropelle, Eduardo Rochete, Cintra, Dennys Esper, Pauli, José Rodrigo
Format:	Article
Language:	eng
Subjects:	Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer’s disease Amyloid beta-Peptides - metabolism Animals Apoptosis Diet, High-Fat - adverse effects Disease Models, Animal Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - physiology Hippocampus - metabolism Inflammation Inflammation - metabolism Interleukin-1beta Mice Mice, Transgenic Microglia - metabolism Neurons - metabolism Phosphorylation Saturated fatty acids Signal Transduction - drug effects tau Proteins - metabolism Temporal Lobe - metabolism β-Amyloid
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Summary:	•Short-term HFD consumption increases hippocampal β-Amyloid and Tau phosphorylation.•This process is associated with increased inflammatory, ER stress and apoptotic signals.•IL1β and β-Amyloid content increases with HFD in different regions of hippocampus. The consumption of saturated fatty acids is one of the leading risk factors for Alzheimer’s Disease (AD) development. Indeed, the short-term consumption of a high-fat diet (HFD) is related to increased inflammatory signals in the hippocampus; however, the potential molecular mechanisms linking it to AD pathogenesis are not fully elucidated. In our study, we investigated the effects of short-term HFD feeding (within 3, 7 and 10 days) in AD markers and neuroinflammation in the hippocampus of mice. The short period of HFD increased fasting glucose and HOMA-IR. Also, mice fed HFD increased the protein content of β-Amyloid, pTau, TNFα, IL1β, pJNK, PTP1B, peIF2α, CHOP, Caspase3, Cleaved-Caspase3 and Alzheimer-related genes (Bax, PS1, PEN2, Aph1b). At 10 days, both neuronal (N2a) and microglial (BV2) cells presented higher expression of inflammatory and apoptotic genes when stimulated with palmitate. These findings suggest that a short period of consumption of a diet rich in saturated fat is associated with activation of inflammatory, ER stress and apoptotic signals in the hippocampus of young mice.
ISSN:	0889-1591 1090-2139