Electrooxidative Amination of sp2 C–H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C–H activation for sp2 C–N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergi...

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Bibliographic Details
Published in:Organic letters 2019-04, Vol.21 (7), p.1968-1972
Main Authors: Kathiravan, Subban, Suriyanarayanan, Subramanian, Nicholls, Ian A
Format: Article
Language:English
Online Access:Get full text
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Summary:Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C–H activation for sp2 C–N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C–H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H2 as the sole and benign byproduct.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b00003