Sensitization in Heart Transplantation: Emerging Knowledge: A Scientific Statement From the American Heart Association

Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate’s access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transpla...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2019-03, Vol.139 (12), p.e553-e578
Main Authors: Colvin, Monica M, Cook, Jennifer L, Chang, Patricia P, Hsu, Daphne T, Kiernan, Michael S, Kobashigawa, Jon A, Lindenfeld, JoAnn, Masri, S Carolina, Miller, Dylan V, Rodriguez, E Rene, Tyan, Dolly B, Zeevi, Adriana
Format: Article
Language:English
Subjects:
Graft Rejection - etiology
Graft Rejection - prevention & control
Heart Transplantation - adverse effects
Histocompatibility Testing
HLA Antigens - immunology
Humans
Immunoglobulins, Intravenous - therapeutic use
Isoantibodies - blood
Isoantibodies - immunology
Plasma Exchange
Plasmapheresis
Rituximab - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate’s access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.
ISSN:0009-7322
1524-4539
DOI:10.1161/CIR.0000000000000598