Three new diterpenes and two new sesquiterpenoids from the endophytic fungus Trichoderma koningiopsis A729

[Display omitted] Three new diterpenes koninginols A-C (1–3) and two new sesquiterpenoids 11-hydroxy-15-drimeneoic acid (4), koninginol D (5), together with twelve known compounds (6–17) were isolated from the endophytic fungus Trichoderma koningiopsis A729 derived from Morinda officinalis. Their st...

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Bibliographic Details
Published in:Bioorganic chemistry 2019-05, Vol.86, p.368-374
Main Authors: Chen, Shanchong, Li, Haohua, Chen, Yuchan, Li, Saini, Xu, Jianlin, Guo, Heng, Liu, Zhaoming, Zhu, Shuang, Liu, Hongxin, Zhang, Weimin
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Bacillus subtilis - drug effects
Cell Proliferation - drug effects
Diterpenes
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Microbial Sensitivity Tests
Molecular Structure
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenoids
Structure-Activity Relationship
Trichoderma - chemistry
Trichoderma koningiopsis
Tumor Cells, Cultured
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Summary:[Display omitted] Three new diterpenes koninginols A-C (1–3) and two new sesquiterpenoids 11-hydroxy-15-drimeneoic acid (4), koninginol D (5), together with twelve known compounds (6–17) were isolated from the endophytic fungus Trichoderma koningiopsis A729 derived from Morinda officinalis. Their structures were fully assigned with the aid of extensive spectroscopic analysis and reported data from the previous literatures. Koninginols A and B were disclosed as intriguing diterpene alkaloids, whereas the koninginol C was disclosed as one of the two examples of harziandione diterpene. All the isolates were evaluated for their antitumor activity, and compounds 1–2, 4–6, 11–13, 16–17 were evaluated for their antibacterial activity, wherein the new compounds 1 and 2 exhibited significant antibacterial activity against Bacillus subtilis with MIC values of 10 and 2 μg/mL, respectively.
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2019.02.005