Interpretation of the effect of CYP2C9, VKORC1 and CYP4F2 variants on warfarin dosing adjustment in Turkey

It was aimed to underline the importance and explain the meaning of genetic testing in warfarin dosing and investigate and evaluate the contributions of the CYP2C9, VKORC1, and CYP4F2 variants in a Turkish population. Two hundred patients were genotyped for CYP2C9 (rs1799853, rs1057910 and rs5616545...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2019-04, Vol.46 (2), p.1825-1833
Main Authors: Kocael, Ahmet, Eronat, Allison Pınar, Tüzüner, Mete Bora, Ekmekçi, Ahmet, Orhan, Ahmet Lütfullah, İkizceli, İbrahim, Yılmaz-Aydoğan, Hülya, Öztürk, Oğuz
Format: Article
Language:English
Subjects:
Adult
Aged
Animal Anatomy
Animal Biochemistry
Biomarkers, Pharmacological
Biomedical and Life Sciences
Cytochrome P-450 CYP2C9 - genetics
Cytochrome P-450 CYP2C9 - metabolism
Cytochrome P450 Family 4 - genetics
Cytochrome P450 Family 4 - metabolism
Data processing
Dosage
Dose-Response Relationship, Drug
Female
Gene Frequency
Genetic screening
Genetic Variation - genetics
Genotype
Histology
Humans
Life Sciences
Male
Middle Aged
Morphology
Nucleotide sequence
Original Article
Pharmacogenetics
Polymorphism, Single Nucleotide
Turkey
Vitamin K Epoxide Reductases - genetics
Vitamin K Epoxide Reductases - metabolism
Warfarin
Warfarin - administration & dosage
Warfarin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It was aimed to underline the importance and explain the meaning of genetic testing in warfarin dosing and investigate and evaluate the contributions of the CYP2C9, VKORC1, and CYP4F2 variants in a Turkish population. Two hundred patients were genotyped for CYP2C9 (rs1799853, rs1057910 and rs56165452), VKORC1 (rs9934438, rs8050894, rs9923231, rs7294 and rs2359612) and CYP4F2 (rs2108622), yet, only 127 patients were found suitable for further evaluation in terms of their personal response to warfarin due to long term usage and available INR and dose usage information. The DNA sequences were determined by the ABI PRISM 3100 Genetic Analyzer to 3130xl System (Applied Biosystems, Foster City, California). Warfarin dose application suggestions by warfaringdosing.org, FDA and MayoClinic were followed. Dose requirements in the Turkish population were found higher than the suggested doses by warfarindosing.org. The multivariate logistic regression analysis reveals the utilization of VCORC1 genetic evaluation is valuable in warfarin dosing (low and moderate vs. high) in this study (p 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-019-04634-9