The association of estimated whole blood viscosity with hemodynamic parameters and prognosis in patients with heart failure

We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction. Total of 542 patients were included and followed-up for median 13 months. Results: The WBV parameters had negative...

Full description

Saved in:
Bibliographic Details
Published in:Biomarkers in medicine 2019-02, Vol.13 (2), p.69-82
Main Authors: Ozcan Cetin, Elif Hande, Cetin, Mehmet Serkan, Ça l, Kumral, Temizhan, Ahmet, Özbay, Mustafa Bilal, Ediboglu, Emek, Özcan Çelebi, Özlem, Aras, Dursun, Topaloglu, Serkan, Aydogdu, Sinan
Format: Article
Language:English
Subjects:
Anemia
Atrium
Biomarkers - analysis
Blood Viscosity - physiology
Cardiac Catheterization
Congestive heart failure
Edema
Female
Follow-Up Studies
Heart failure
Heart Failure - blood
Heart Failure - pathology
heart failure with reduced ejection fraction
Hemodynamics
Hemoglobin
Humans
Intubation
Laboratories
Male
Medical prognosis
Middle Aged
Mortality
Patients
Prognosis
Pulmonary arteries
Pulmonary hypertension
Retrospective Studies
right heart catheterization
Risk factors
shear rate
Shear stress
Studies
Systematic review
Viscosity
whole blood viscosity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction. Total of 542 patients were included and followed-up for median 13 months. Results: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. The WBV parameters were found to be independent predictors of composite end point (CEP) and all-cause mortality. Every one cP increases of WBV(h) and WBV(l) were associated with 17 and 1% reductions of CEP. In Kaplan-Meier analysis, patients with low WBV quartiles were found to have significantly more CEP. Being an easily accessible and costless prognosticator, WBV seems to be a novel marker for determining prognosis and an emerging tool to individualize heart failure with reduced ejection fraction management.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2018-0309