A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female

Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the region...

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Bibliographic Details
Published in:International journal of impotence research 2019-11, Vol.31 (6), p.432-438
Main Authors: Kim, Gwang-Won, Kim, Yun-Hyeon, Park, Kwangsung, Jeong, Gwang-Woo
Format: Article
Language:English
Subjects:
Adult
Algorithms
Brain
Brain research
Comparative analysis
Estradiol
Female
Follicle-stimulating hormone
Glycoproteins
Gonadal Steroid Hormones - blood
Gonadal Steroid Hormones - therapeutic use
Gyrus Cinguli - diagnostic imaging
Health aspects
Hormone replacement therapy
Hormones
Humans
Luteinizing hormone
Magnetic Resonance Imaging
Male
Middle Aged
Neurology
Parietal Lobe - diagnostic imaging
Pharmaceutical industry
Postoperative Period
Sex Reassignment Surgery
Software
Temporal Lobe - diagnostic imaging
Testosterone
Testosterone - blood
Transsexualism
Transsexuality
Transsexuals
White Matter - diagnostic imaging
Women
Womens health
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Summary:Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the regional WM volume differences between postoperative FtM transsexuals and female controls using voxel-based morphometry (VBM) and further to assess the correlations between regional volume variations and cross-sex hormones. WM volume was assessed in 12 postoperative FtM transsexuals receiving cross-sex hormones with 16 age-matched female controls. WM volume was processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Serum sex hormones, including estriol, free testosterone (free-T), estradiol, follicle-stimulating hormone, and luteinizing hormone were measured. Postoperative FtM transsexuals showed significantly (p 
ISSN:0955-9930
1476-5489
DOI:10.1038/s41443-019-0111-5