Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer

To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue. The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. The control groups...

Full description

Saved in:
Bibliographic Details
Published in:Journal of laryngology and otology 2018-12, Vol.132 (12), p.1134-1137
Main Authors: Elwany, S, Radi, S, Khalil, H, Talaat, I, Belasy, K
Format: Article
Language:English
Subjects:
Adult
Age
Antigens
Biopsy
CD8-Positive T-Lymphocytes - pathology
Cytotoxicity
Enzymes
Female
Humans
Immunology
Immunotherapy
Laryngeal cancer
Laryngeal carcinoma
Laryngeal Mucosa - pathology
Laryngeal Neoplasms - pathology
Laryngectomy
Larynx
Lymphocytes
Lymphocytes T
Main Articles
Male
Middle Aged
Mucosa
Otolaryngology
Smokers
Smoking
Smoking - adverse effects
Statistical analysis
Surgery
Tobacco
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue. The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. The control groups included 10 smokers and 10 non-smokers who were scheduled for microlaryngeal surgery. Specimens from the three groups were processed for histopathological and histochemical evaluation. In patients without cancer of the larynx, the number of cluster of differentiation 8 lymphocytes was greater in smokers than non-smokers. The number of cluster of differentiation 8 lymphocytes was greatest in smokers with laryngeal cancer, and the difference between this group and the two control groups was statistically significant. The study showed that smoking increased the number of cluster of differentiation 8 T-lymphocytes in the laryngeal mucosa. The increase was greatest in patients who had developed laryngeal cancer.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215118002244