A review of complementary therapies with medicinal plants for chemotherapy-induced peripheral neuropathy

•Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, prolonged, and often irreversible side effect of many chemotherapeutic agents.•Medicinal plants are considered to be the most common complementary therapy modalities for CIPN. Therefore, we identified ten medicinal herbal extracts...

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Bibliographic Details
Published in:Complementary therapies in medicine 2019-02, Vol.42, p.226-232
Main Authors: Wu, Bei-Yu, Liu, Chun-Ting, Su, Yu-Li, Chen, Shih-Yu, Chen, Yung-Hsiang, Tsai, Ming-Yen
Format: Article
Language:English
Subjects:
Antineoplastic drugs
Apoptosis
Cancer
Cancer therapies
Cell cycle
Chemotherapy
Complementary medicine
Deoxyribonucleic acid
DNA
Drug development
Drug dosages
Drugs
Herbal medicine
Inflammation
Medicinal plants
Mitochondrial DNA
Nervous system
Neurotoxicity
Oxidative stress
Pain
Peripheral neuropathy
Plant extracts
Quality of life
Side effects
Spinal cord
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Summary:•Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, prolonged, and often irreversible side effect of many chemotherapeutic agents.•Medicinal plants are considered to be the most common complementary therapy modalities for CIPN. Therefore, we identified ten medicinal herbal extracts as well as their phytochemicals, and three herbal formulas.•Multiple complementary therapies have been used and studied for decades, and their effects against CIPN are focus on anti-oxidative activity.•Novel therapies or drugs that have proven to be effective in animals require further investigation, so confirmation of their efficacy and safety will require time. Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, prolonged, and often irreversible side effect of many chemotherapeutic agents. The development of neuropathic pain is still poorly managed by clinically available drugs at present. In this mini-review, we summarized the current knowledge of pathobiology for CIPN, and selected evidence on the application of complementary therapies in experimental studies. Medicinal plants are considered to be the most common complementary therapy modalities for CIPN. Therefore, we identified ten medicinal herbal extracts as well as their phytochemicals, and three herbal formulas. Multiple complementary therapies have been used and studied for decades, and their effects against CIPN are focus on anti-oxidative activity. However, there is still controversial due to the diverse manifestations of different antineoplastic agents and complex drug interactions. Novel therapies or drugs that have proven to be effective in animals require further investigation, so confirmation of their efficacy and safety will require time.
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2018.11.022