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Porphyromonas gingivalis lipopolysaccharide-induced periodontitis and serum amyloid-beta peptides
•Experimental periodontitis is associated with an acute overexpression of Aβ1–40.•Experimental periodontitis is associated with long-term increase of Aβ1–42.•Loos of bone around teeth due to periodontitis correlates with high levels of Aβ peptides. The aim of this investigation was to determine the...
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Published in: | Archives of oral biology 2019-03, Vol.99, p.120-125 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Experimental periodontitis is associated with an acute overexpression of Aβ1–40.•Experimental periodontitis is associated with long-term increase of Aβ1–42.•Loos of bone around teeth due to periodontitis correlates with high levels of Aβ peptides.
The aim of this investigation was to determine the circulating levels of amyloid beta (Aβ) peptides using the Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) model to induce periodontitis.
Experimental periodontitis was induced in 6 male Sprague-Dawley rats. Alveolar bone loss was measure by micro computed tomography. Serum concentrations of Aβ1–40 and Aβ1–42 prior to periodontal induction, at 24 h, 7, 14, and 21 days the last injection of Pg-LPS.
The distance between the cemento-enamel junction and the bone crest (i.e., alveolar bone loss) was significantly higher at the end of periodontal induction compared to baseline (2.92 ± 0.29 mm vs. 3.8 ± 0.28 mm, P |
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ISSN: | 0003-9969 1879-1506 |
DOI: | 10.1016/j.archoralbio.2019.01.008 |