Associations of metabolically healthy obesity with prevalence and progression of coronary artery calcification: Results from the Heinz Nixdorf Recall Cohort Study

There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. So far, associations between MHO and coronary artery calcification (CAC), a measure of subclinical atherosclerosis, have mainly been studied cross...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2019-03, Vol.29 (3), p.228-235
Main Authors: Kowall, B., Lehmann, N., Mahabadi, A.A., Moebus, S., Erbel, R., Jöckel, K.H., Stang, A.
Format: Article
Language:English
Subjects:
Aged
Cohort study
Computed Tomography Angiography
Coronary Angiography - methods
Coronary artery calcification
Coronary artery calcium
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Cross-Sectional Studies
Disease Progression
Female
Germany - epidemiology
Humans
Longitudinal Studies
Male
Metabolic syndrome
Metabolically healthy obesity
Middle Aged
Obesity, Metabolically Benign - diagnosis
Obesity, Metabolically Benign - epidemiology
Prevalence
Prognosis
Prospective Studies
Risk Factors
Subclinical atherosclerosis
Time Factors
Vascular Calcification - diagnostic imaging
Vascular Calcification - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. So far, associations between MHO and coronary artery calcification (CAC), a measure of subclinical atherosclerosis, have mainly been studied cross-sectionally in Asian populations. We assessed cross-sectional and longitudinal MHO CAC associations in a Caucasian population. In the Heinz Nixdorf Recall Study, a population-based cohort study in Germany, CAC was assessed by electron-beam tomography at baseline and at 5-year follow-up. For cross-sectional and longitudinal analyses, we included 1585 participants free of coronary heart disease at baseline, with CAC measurements at baseline and at follow-up, and with either normal weight (BMI 18.5–24.9 kg/m2) or obesity (BMI ≥30.0 kg/m2) at baseline. We used four definitions of MHO. In our main analysis, we defined obese persons as metabolically healthy if they met ≤1 of the NCEP ATP III criteria for the definition of the metabolic syndrome – waist circumference was not taken into account because of collinearity with BMI. Persons with MHO had a higher prevalence of CAC than metabolically healthy normal weight (MHNW) persons (prevalence ratio = 1.59 (95% confidence interval 1.38–1.84) for the main analysis). Persons with MHO had slightly larger odds of CAC progression than persons with MHNW (odds ratios ranged from 1.17 (0.69–1.99) to 1.48 (1.02–2.13) depending on MHO definition and statistical approach). Our analyses on MHO CAC associations add to the evidence that MHO is not a purely benign health condition. •Metabolically healthy obesity (MHO) is not a stable condition.•MHO is not benign in view of prevalent coronary artery calcium.•MHO is not benign in view of progression of coronary artery calcium.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2018.11.002