A facile quantification of hyaluronic acid and its crosslinking using gas-phase electrophoresis

We report a facile, high-resolution approach to quantitatively characterize hyaluronic acid (HA) and study its crosslinking reaction using electrospray-differential mobility analysis (ES-DMA). Mobility size distributions, number concentrations, molecular mass distributions, and polydispersity index...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2019-03, Vol.411 (7), p.1443-1451
Main Authors: Wang, Hung-Li, Huang, Chin-Ping, Su, Chiu-Hun, Tsai, De-Hao
Format: Article
Language:English
Subjects:
Activation energy
Analytical Chemistry
Biochemistry
Butanediol
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Chromatography
Crosslinking
Electrophoresis
Electrophoretic mobility
Food Science
Glycols (Class of compounds)
Hyaluronic acid
Laboratory Medicine
Measurement
Mobility
Monitoring/Environmental Analysis
Polydispersity
Polymer crosslinking
Research Paper
Size exclusion chromatography
Time dependence
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Summary:We report a facile, high-resolution approach to quantitatively characterize hyaluronic acid (HA) and study its crosslinking reaction using electrospray-differential mobility analysis (ES-DMA). Mobility size distributions, number concentrations, molecular mass distributions, and polydispersity index of HAs were obtained successfully via a rapid analysis by ES-DMA (
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-019-01584-w