A maternal high-fat diet may accelerate adipo-immunologic aging in offspring

Maternal obesity and improper nutrition predispose offspring to chronic metabolic diseases. Although the frequency of these diseases increases with aging, the effect of a maternal high-fat diet on aged offspring remains elusive. C57BL/6J female mice were fed a high-fat (HF) diet or a control (CON) d...

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Bibliographic Details
Published in:	Life sciences (1973) 2019-02, Vol.219, p.100-108
Main Authors:	Imai, Atsuko, Fujimoto, Eka, Tamura, Kaho, Utsuyama, Masanori, Sato, Kazuto
Format:	Article
Language:	eng
Subjects:	Adipose tissue Immunologic aging Inflammation Maternal high-fat diet Non-alcoholic fatty liver disease Offspring
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Summary:	Maternal obesity and improper nutrition predispose offspring to chronic metabolic diseases. Although the frequency of these diseases increases with aging, the effect of a maternal high-fat diet on aged offspring remains elusive. C57BL/6J female mice were fed a high-fat (HF) diet or a control (CON) diet and then mated. All offspring remained with their birth dam until weaning at 3 weeks. After weaning, the offspring from the HF and CON diet-fed dams were given either the HF diet or CON diet, which resulted in four groups: CON/CON, CON/HF, HF/CON, and HF/HF. All mice were immunized with ovalbumin and then sacrificed at 70 weeks. The body weights in offspring from dam exposed to a HF diet were significantly higher than those in offspring from dam fed a CON diet in the early stage of life but then became lower in the later stage of life. The serum adiponectin levels were lower in offspring from dam exposed to a HF diet and were correlated with adiposity measured by visceral and subcutaneous fat mass. Non-alcoholic fatty liver disease was much more severe in the livers of offspring from the maternal HF groups. In particular, lobular inflammation and fibrosis were prominent in the HF/HF group. Regarding immunological parameters, senescence-associated T cells were increased, and natural killer T cells were decreased by the effect of both maternal and offspring HF diet. We have demonstrated that a maternal high-fat diet may accelerate the adipo-immunologic aging process.
ISSN:	0024-3205 1879-0631