Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats

We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue. Rats received either OPZ, LPZ...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2019-06, Vol.456 (1-2), p.105-113
Main Authors: Patil, Ashwini S., Singh, Alok D., Mahajan, Umesh B., Patil, Chandragouda R., Ojha, Shreesh, Goyal, Sameer N.
Format: Article
Language:English
Subjects:
Animal tissues
Animals
Antioxidants
Biochemistry
Biomedical and Life Sciences
Cardiology
Catalase
Cytokines
Depletion
Electrocardiography
Heart attacks
Hemodynamics
Inflammation
Isoproterenol
Lansoprazole - pharmacology
Life Sciences
Male
Malondialdehyde - metabolism
Medical Biochemistry
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardium - metabolism
Myocardium - pathology
Necrosis
Nitric Oxide - metabolism
Omeprazole
Omeprazole - pharmacology
Oncology
Oxidative stress
Oxidative Stress - drug effects
Parameter estimation
Rats
Rats, Wistar
Reactive oxygen species
Rodents
Toxicity
Tumor necrosis factor-α
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Summary:We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue. Rats received either OPZ, LPZ (50 mg/kg/day, p.o.) individually for 7 days with concurrent administration of isoproterenol (ISO) (150 mg/kg, s.c.) on 6th and 7th day of study period to induce myocardial infarction. On the 8th day after measuring hemodynamic parameters, rats were killed and parameters were evaluated. ECG waves were found to be normal in the treatment group. ISO control rats revealed escalation in the oxidative stress as evidenced by depletion in the content of SOD, GSH, catalase and increase in the level of MDA and NO as compared with the normal rats. Treatment with OPZ and LPZ significantly reduced the ROS, indicated by an increase in the endogenous antioxidants and a decrease in NO and MDA levels. ISO control rats showed a significant elevation in the levels of pro-inflammatory cytokine TNF-α as compared to the normal and treatment group of rats. Administration of OPZ and LPZ does not exhibit any significant toxicity. Our findings reveal that multiple doses of OPZ and LPZ may have distinctly minimized the ISO-induced myocardial necrosis by declining the hmodynamic parameters, oxidative stress and pro-inflammatory cytokine TNF-α in myocardial infarcted rats.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-019-03494-y