Association Between Total Cholesterol and 5 year Mortality in Patients with Carotid Artery Stenosis and Poststroke Functional Dependence

Background: Aggressive lipid-lowering treatment reduces the risk of cardiovascular events, but remains controversial in stroke patients. We investigate the influence of total cholesterol level on 5-year outcomes of ischemic stroke patients with high-grade internal carotid artery (ICA) stenosis and p...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2019-04, Vol.28 (4), p.1040-1047
Main Authors: Lung, Yen-Ju, Weng, Wei-Chieh, Wu, Chia-Lun, Huang, Wen-Yi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
carotid artery stenosis
Carotid Stenosis - blood
Carotid Stenosis - diagnosis
Carotid Stenosis - mortality
Carotid Stenosis - physiopathology
Cholesterol - blood
Comorbidity
Disability Evaluation
Female
functional dependence
Humans
Hyperlipidemias - blood
Hyperlipidemias - diagnosis
Hyperlipidemias - mortality
ischemic stroke
lower cholesterol
Male
Middle Aged
mortality
Prevalence
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke - blood
Stroke - diagnosis
Stroke - mortality
Stroke - physiopathology
stroke outcome
Taiwan - epidemiology
Time Factors
Total cholesterol
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Summary:Background: Aggressive lipid-lowering treatment reduces the risk of cardiovascular events, but remains controversial in stroke patients. We investigate the influence of total cholesterol level on 5-year outcomes of ischemic stroke patients with high-grade internal carotid artery (ICA) stenosis and poststroke functional dependence. Methods: One-hundred and ninety-six acute ischemic stroke patients with high-grade ICA stenosis and modified Rankin Scale score ≥ 3 upon discharge were enrolled and prospectively observed for 5 years. Patients were divided into 2 groups according to total cholesterol level at admission: ≥200 mg/dL or
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2018.12.030