Protective effect of atorvastatin on oxidative stress in streptozotocin‐induced diabetic rats independently their lipid‐lowering effects

In the present study, we investigate the effects of atorvastatin on the lipid profile, oxidative stress, and liver enzyme markers, and its protective activity against diabetic complications, in streptozotocin (STZ)‐induced diabetic rats. Fasting blood glucose (FBG), triglyceride (TG), total choleste...

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Published in:Journal of biochemical and molecular toxicology 2019-05, Vol.33 (5), p.e22295-n/a
Main Authors: Aktay, Göknur, Gürsoy, Şule Öner, Uyumlu, Umut, Ünüvar, Songül, İlhan, Nevin
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Aspartate aminotransferase
Atorvastatin
Brain
Cholesterol
Complications
Diabetes
Diabetes mellitus
Enzymatic activity
Enzymes
Heart
High density lipoprotein
Kidneys
Lipid peroxidation
Lipids
liver enzymes
Nitric oxide
Oxidative stress
Peroxidation
Statins
Streptozocin
streptozotocin (STZ)
Thiobarbituric acid
Tissues
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Summary:In the present study, we investigate the effects of atorvastatin on the lipid profile, oxidative stress, and liver enzyme markers, and its protective activity against diabetic complications, in streptozotocin (STZ)‐induced diabetic rats. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), and high‐density lipoprotein (HDL) levels, as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme activities, were measured 7 weeks after the administration of STZ and atorvastatin. Thiobarbituric acid reactive substances (TBARS), non‐protein associated sulfhydryl (NP‐SH), total sulfhydryl (T‐SH), and nitric oxide (NO) levels were measured to evaluate oxidative stress. Atorvastatin was found to inhibit ALT and AST activities and to reduce FBG levels in rats with STZ‐induced diabetes. Moreover, atorvastatin treatment significantly reduced lipid peroxidation in kidney, heart, and eye tissues (P 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22295