The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

A fast and green protocol for the Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor was developed. In contrast with existing methods, this method is simple (35 min), uses mild reaction conditions (45 °C) and is envi...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2019-01, Vol.17 (4), p.807-812
Main Authors: Du, Li-Hua, Dong, Zhen, Long, Rui-Jie, Chen, Ping-Feng, Xue, Miao, Luo, Xi-Ping
Format: Article
Language:English
Subjects:
Acrylates
Continuous flow
Imidazole
Innovations
Microreactors
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Summary:A fast and green protocol for the Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor was developed. In contrast with existing methods, this method is simple (35 min), uses mild reaction conditions (45 °C) and is environmentally friendly. This enzymatic Michael addition performed in continuous flow microreactors is an innovation that may open up the use of enzymatic microreactors in imidazole analogue biotransformations.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02533a