Clinical Microbiology Is Growing Up: The Total Laboratory Automation Revolution

Historically, culture-based microbiology laboratory testing has relied on manual methods, and automated methods (such as those that have revolutionized clinical chemistry and hematology over the past several decades) were largely absent from the clinical microbiology laboratory. However, an increase...

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Bibliographic Details
Published in:	Clinical chemistry (Baltimore, Md.) Md.), 2019-05, Vol.65 (5), p.634-643
Main Authors:	Bailey, Adam L, Ledeboer, Nathan, Burnham, Carey-Ann D
Format:	Article
Language:	eng
Subjects:	Antibiotics Artificial intelligence Automation Bacteriology Clinical microbiology Colony Count, Microbial Culture Economic conditions Efficiency, Organizational Hematology Historical account Humans Laboratories - organization & administration Laboratory tests Literature reviews Medical equipment and supplies industry Medical laboratories Medical test kit industry Microbial Sensitivity Tests Microbiological Techniques - instrumentation Microbiology Microorganisms Organic chemistry Standardization Technologists Time and Motion Studies Training Urine Workforce
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Summary:	Historically, culture-based microbiology laboratory testing has relied on manual methods, and automated methods (such as those that have revolutionized clinical chemistry and hematology over the past several decades) were largely absent from the clinical microbiology laboratory. However, an increased demand for microbiology testing and standardization of sample-collection devices for microbiology culture, as well as a dwindling supply of microbiology technologists, has driven the adoption of automated methods for culture-based laboratory testing in clinical microbiology. We describe systems currently enabling total laboratory automation (TLA) for culture-based microbiology testing. We describe the general components of a microbiology automation system and the various functions of these instruments. We then introduce the 2 most widely used systems currently on the market: Becton Dickinson's Kiestra TLA and Copan's WASPLab. We discuss the impact of TLA on metrics such as turnaround time and recovery of microorganisms, providing a review of the current literature and perspectives from laboratory directors, managers, and technical staff. Finally, we provide an outlook for future advances in TLA for microbiology with a focus on artificial intelligence for automated culture interpretation. TLA is playing an increasingly important role in clinical microbiology. Although challenges remain, TLA has great potential to affect laboratory efficiency, turnaround time, and the overall quality of culture-based microbiology testing.
ISSN:	0009-9147 1530-8561