Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study

Purpose It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study. Methods From Jul...

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Published in:Strahlentherapie und Onkologie 2019-05, Vol.195 (5), p.412-419
Main Authors: Nakamura, Katsumasa, Ohga, Saiji, Yorozu, Atsunori, Saito, Shiro, Kikuchi, Takashi, Dokiya, Takushi, Fukushima, Masanori, Yamanaka, Hidetoshi
Format: Article
Language:English
Subjects:
Brachytherapy - standards
Clinical Competence - standards
Cohort analysis
Cohort Studies
Hospitals, High-Volume - standards
Humans
Implantation
Iodine Radioisotopes - therapeutic use
Male
Medicine
Medicine & Public Health
Oncology
Organs at Risk - radiation effects
Original Article
Parameters
Patients
Prospective Studies
Prostate cancer
Quality Assurance, Health Care - standards
Radiometry
Radiotherapy
Rectum
Rectum - radiation effects
Treatment Outcome
Urethra - radiation effects
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Summary:Purpose It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study. Methods From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. As a surrogate for institutional experience, we classified the J‑POPS institutions as high-volume (patient accrual volume was ≥120 patients per institution) or low-volume institutions (patient accrual volume was 144 Gy of D90, whereas in the 20 low-volume institutions ( n  = 525) some of the patients were treated with 90%, whereas in the low-volume institutions a considerable percentage of patients showed lower V100. Although there was no correlation between D90 and rectal dose parameters, UD90 had a moderate positive correlation with D90 in both the high- and low-volume institutions. U200 varied more widely in the low-volume institutions. Conclusions Our findings indicate that the institutional patient accrual volume is associated with the treatment quality of I‑125 prostate seed implantation.
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-018-1407-y