Engineering cyanobacteria for production of terpenoids

Terpenoids are a diverse group of natural products with a variety of commercial applications. With recent advances in synthetic biology and metabolic engineering, microbial terpenoid synthesis is being viewed as a feasible approach for industrial production. Among different microbial hosts, cyanobac...

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Bibliographic Details
Published in:Planta 2019-01, Vol.249 (1), p.145-154
Main Authors: Lin, Po-Cheng, Pakrasi, Himadri B.
Format: Article
Language:English
Subjects:
Agriculture
Biomedical and Life Sciences
Carbon dioxide
Cyanobacteria
Cyanobacteria - metabolism
Ecology
Farnesene
Forestry
Industrial production
Isoprene
Life Sciences
Light
Limonene
Metabolic Engineering
Microorganisms
Natural products
Photosynthesis
Plant Sciences
REVIEW
Terpenes
Terpenes - metabolism
Terpenes and Isoprenoids
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Summary:Terpenoids are a diverse group of natural products with a variety of commercial applications. With recent advances in synthetic biology and metabolic engineering, microbial terpenoid synthesis is being viewed as a feasible approach for industrial production. Among different microbial hosts, cyanobacteria have the potential of sustainable production of terpenoids using light and CO₂. Terpene synthases and the precursor pathways have been expressed in cyanobacteria for enhanced production of various terpene hydrocarbons, including isoprene, limonene, β-phellandrene, and farnesene. However, the productivities need to be further improved for commercial production. Many barriers remain to be overcome in order to efficiently convert CO₂ to terpenoids. In this review, we will summarize recent efforts on photosynthetic production of terpenoids and discuss the challenges and opportunities of engineering cyanobacteria for terpenoid bioproduction.
ISSN:0032-0935
1432-2048
DOI:10.1007/s00425-018-3047-y