Quantitative assessment of mesorectal fat: new prognostic biomarker in patients with mid-to-lower rectal cancer

Objectives To investigate the impact of mesorectal fat area (MFA) on oncologic outcomes in patients with mid-to-lower rectal cancer who received curative-intent surgery. Methods Patients with mid-to-lower rectal cancer who underwent preoperative abdominopelvic computed tomography (CT) and curative-i...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2019-03, Vol.29 (3), p.1240-1247
Main Authors: Yoon, Jiyoung, Chung, Yong Eun, Lim, Joon Seok, Kim, Myeong-Jin
Format: Article
Language:English
Subjects:
Biomarkers
Body mass
Body Mass Index
Cancer
Colorectal cancer
Computed tomography
Diagnostic Radiology
Disease-Free Survival
Female
Humans
Imaging
Internal Medicine
Interventional Radiology
Intra-Abdominal Fat - diagnostic imaging
Male
Mathematical analysis
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Multidetector Computed Tomography - methods
Neoplasm Staging - methods
Neuroradiology
Oncology
Patients
Prognosis
Radiology
Rectal Neoplasms - diagnosis
Rectum
Rectum - diagnostic imaging
Regression analysis
Surgery
Survival
Test procedures
Tumors
Ultrasound
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To investigate the impact of mesorectal fat area (MFA) on oncologic outcomes in patients with mid-to-lower rectal cancer who received curative-intent surgery. Methods Patients with mid-to-lower rectal cancer who underwent preoperative abdominopelvic computed tomography (CT) and curative-intent surgery in 2011 were divided into two groups by tumour recurrence (group A) or no recurrence (group B) during a 5-year follow-up. Visceral fat area (VFA) and MFA were measured on preoperative CT and cutoff values were calculated using the Youden index. Univariate and multivariate regression analyses including BMI, VFA, and MFA were performed to investigate meaningful prognostic biomarkers. The Kaplan–Meier method with log-rank testing was used to validate prognostic biomarkers. Results Group A contained 42 patients and group B had 155 patients. Cutoff values were 25 kg/m 2 for BMI, 130 cm 2 for VFA, and 10 cm 2 for MFA using the Youden index. On multivariate Cox regression analysis, MFA (odds ratio [OR] = 0.426, p = 0.010), TNM stage ( p = 0.027), and perioperative complication grade ( p = 0.028) were significantly different between groups. BMI and VFA did not show significant differences. By the Kaplan–Meier method with log-rank testing, disease-free survival (DFS) was significantly longer in patients with MFA ≥10 cm 2 compared to patients with MFA
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-018-5723-5