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Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors
Objective The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematos...
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| Published in: | Lupus 2019-02, Vol.28 (2), p.210-216 |
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| container_title | Lupus |
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| creator | Cavazzana, I Piantoni, S Sciatti, E Fredi, M Taraborelli, M Bonadei, I Airò, P Metra, M Tincani, A Franceschini, F Vizzardi, E |
| description | Objective
The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.
Methods
Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping.
Results
SLE ED+ more frequently showed NVC abnormalities compared with HCs (p |
| doi_str_mv | 10.1177/0961203318821161 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2164103349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203318821161</sage_id><sourcerecordid>2164103349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-7ea2efc4ca381f5cd7a54b25a1b63cfc6fba2337e84ba147729bc743a619fcbe3</originalsourceid><addsrcrecordid>eNp1kU2L1TAUhoMozp3RvSsJuBGu1Xy0abscqqPCgDAouCvp6encjG1T8zFDf5b_0JQ7Kgy4CCE5z3lP8r6EvODsLedl-Y7VigsmJa8qwbnij8iO52WZpXvxmOy2crbVT8ip9zeMMclr9ZScSKZYJZjakV9XOOpg7OwPZqEdhjvEmeLc23DA0eiR9qsf4gwb84bemh4t6MWMo3bWg11WqueegnEQN6H5mjbv5T4tvm--N1f5no7rtBwsrAE9NTP1qw84GaBjXKKn6NY0adLB-nS6M-FgY6CgXW_srfabqqPO-B900BCs88_Ik0GPHp_f72fk28WHr82n7PLLx8_N-WUGUhUhK1ELHCAHLSs-FNCXusg7UWjeKQkDqKHTQsoSq7zTm2mi7qDMpVa8HqBDeUZeH3UXZ39G9KGdjAdMH5_RRt8KrnKevM3rhL56gN7Y6Ob0ukSVvChyoTaKHSlIznmHQ7s4M2m3tpy1W5ztwzhTy8t74dhN2P9t-JNfArIj4PU1_pv6X8Hfhy2r7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2171554269</pqid></control><display><type>article</type><title>Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors</title><source>Sage Journals Online</source><creator>Cavazzana, I ; Piantoni, S ; Sciatti, E ; Fredi, M ; Taraborelli, M ; Bonadei, I ; Airò, P ; Metra, M ; Tincani, A ; Franceschini, F ; Vizzardi, E</creator><creatorcontrib>Cavazzana, I ; Piantoni, S ; Sciatti, E ; Fredi, M ; Taraborelli, M ; Bonadei, I ; Airò, P ; Metra, M ; Tincani, A ; Franceschini, F ; Vizzardi, E</creatorcontrib><description>Objective
The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.
Methods
Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping.
Results
SLE ED+ more frequently showed NVC abnormalities compared with HCs (p < 0.0001) in terms of minor alterations (p = 0.017), lower capillary numbers (p = 0.0035) and major alterations. SLE ED + showed a higher rate of CD3 + CD31 + CXCR4 + lymphocytes compared with SLE ED– and with HCs. NVC + SLE showed a significantly reduced rate of total CD3 + cells, but a higher rate and absolute number of CD3 + CD31 + CXCR4 + , compared with NVC– SLE.
Conclusion
NVC alterations are frequent in SLE without any CV risk factors and CVD. They are associated with ED and increased circulating CD3 + CD31 + CXCR4 + lymphocytes. These findings demonstrate a clear microvascular perturbation in patients with short disease duration, low disease activity and no CV risk factors.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203318821161</identifier><identifier>PMID: 30608206</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Angiogenesis ; Cardiovascular diseases ; CD3 antigen ; CXCR4 protein ; Diabetes mellitus ; Doppler effect ; Echocardiography ; Hypercholesterolemia ; Lupus ; Lymphocytes ; Lymphocytes T ; Microvasculature ; Peripheral blood ; Risk factors ; Smoking ; Systemic lupus erythematosus</subject><ispartof>Lupus, 2019-02, Vol.28 (2), p.210-216</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-7ea2efc4ca381f5cd7a54b25a1b63cfc6fba2337e84ba147729bc743a619fcbe3</citedby><cites>FETCH-LOGICAL-c365t-7ea2efc4ca381f5cd7a54b25a1b63cfc6fba2337e84ba147729bc743a619fcbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30608206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavazzana, I</creatorcontrib><creatorcontrib>Piantoni, S</creatorcontrib><creatorcontrib>Sciatti, E</creatorcontrib><creatorcontrib>Fredi, M</creatorcontrib><creatorcontrib>Taraborelli, M</creatorcontrib><creatorcontrib>Bonadei, I</creatorcontrib><creatorcontrib>Airò, P</creatorcontrib><creatorcontrib>Metra, M</creatorcontrib><creatorcontrib>Tincani, A</creatorcontrib><creatorcontrib>Franceschini, F</creatorcontrib><creatorcontrib>Vizzardi, E</creatorcontrib><title>Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objective
The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.
Methods
Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping.
Results
SLE ED+ more frequently showed NVC abnormalities compared with HCs (p < 0.0001) in terms of minor alterations (p = 0.017), lower capillary numbers (p = 0.0035) and major alterations. SLE ED + showed a higher rate of CD3 + CD31 + CXCR4 + lymphocytes compared with SLE ED– and with HCs. NVC + SLE showed a significantly reduced rate of total CD3 + cells, but a higher rate and absolute number of CD3 + CD31 + CXCR4 + , compared with NVC– SLE.
Conclusion
NVC alterations are frequent in SLE without any CV risk factors and CVD. They are associated with ED and increased circulating CD3 + CD31 + CXCR4 + lymphocytes. These findings demonstrate a clear microvascular perturbation in patients with short disease duration, low disease activity and no CV risk factors.</description><subject>Angiogenesis</subject><subject>Cardiovascular diseases</subject><subject>CD3 antigen</subject><subject>CXCR4 protein</subject><subject>Diabetes mellitus</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Hypercholesterolemia</subject><subject>Lupus</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Microvasculature</subject><subject>Peripheral blood</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Systemic lupus erythematosus</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kU2L1TAUhoMozp3RvSsJuBGu1Xy0abscqqPCgDAouCvp6encjG1T8zFDf5b_0JQ7Kgy4CCE5z3lP8r6EvODsLedl-Y7VigsmJa8qwbnij8iO52WZpXvxmOy2crbVT8ip9zeMMclr9ZScSKZYJZjakV9XOOpg7OwPZqEdhjvEmeLc23DA0eiR9qsf4gwb84bemh4t6MWMo3bWg11WqueegnEQN6H5mjbv5T4tvm--N1f5no7rtBwsrAE9NTP1qw84GaBjXKKn6NY0adLB-nS6M-FgY6CgXW_srfabqqPO-B900BCs88_Ik0GPHp_f72fk28WHr82n7PLLx8_N-WUGUhUhK1ELHCAHLSs-FNCXusg7UWjeKQkDqKHTQsoSq7zTm2mi7qDMpVa8HqBDeUZeH3UXZ39G9KGdjAdMH5_RRt8KrnKevM3rhL56gN7Y6Ob0ukSVvChyoTaKHSlIznmHQ7s4M2m3tpy1W5ztwzhTy8t74dhN2P9t-JNfArIj4PU1_pv6X8Hfhy2r7g</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Cavazzana, I</creator><creator>Piantoni, S</creator><creator>Sciatti, E</creator><creator>Fredi, M</creator><creator>Taraborelli, M</creator><creator>Bonadei, I</creator><creator>Airò, P</creator><creator>Metra, M</creator><creator>Tincani, A</creator><creator>Franceschini, F</creator><creator>Vizzardi, E</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors</title><author>Cavazzana, I ; Piantoni, S ; Sciatti, E ; Fredi, M ; Taraborelli, M ; Bonadei, I ; Airò, P ; Metra, M ; Tincani, A ; Franceschini, F ; Vizzardi, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-7ea2efc4ca381f5cd7a54b25a1b63cfc6fba2337e84ba147729bc743a619fcbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiogenesis</topic><topic>Cardiovascular diseases</topic><topic>CD3 antigen</topic><topic>CXCR4 protein</topic><topic>Diabetes mellitus</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Hypercholesterolemia</topic><topic>Lupus</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Microvasculature</topic><topic>Peripheral blood</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cavazzana, I</creatorcontrib><creatorcontrib>Piantoni, S</creatorcontrib><creatorcontrib>Sciatti, E</creatorcontrib><creatorcontrib>Fredi, M</creatorcontrib><creatorcontrib>Taraborelli, M</creatorcontrib><creatorcontrib>Bonadei, I</creatorcontrib><creatorcontrib>Airò, P</creatorcontrib><creatorcontrib>Metra, M</creatorcontrib><creatorcontrib>Tincani, A</creatorcontrib><creatorcontrib>Franceschini, F</creatorcontrib><creatorcontrib>Vizzardi, E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavazzana, I</au><au>Piantoni, S</au><au>Sciatti, E</au><au>Fredi, M</au><au>Taraborelli, M</au><au>Bonadei, I</au><au>Airò, P</au><au>Metra, M</au><au>Tincani, A</au><au>Franceschini, F</au><au>Vizzardi, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2019-02</date><risdate>2019</risdate><volume>28</volume><issue>2</issue><spage>210</spage><epage>216</epage><pages>210-216</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective
The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.
Methods
Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping.
Results
SLE ED+ more frequently showed NVC abnormalities compared with HCs (p < 0.0001) in terms of minor alterations (p = 0.017), lower capillary numbers (p = 0.0035) and major alterations. SLE ED + showed a higher rate of CD3 + CD31 + CXCR4 + lymphocytes compared with SLE ED– and with HCs. NVC + SLE showed a significantly reduced rate of total CD3 + cells, but a higher rate and absolute number of CD3 + CD31 + CXCR4 + , compared with NVC– SLE.
Conclusion
NVC alterations are frequent in SLE without any CV risk factors and CVD. They are associated with ED and increased circulating CD3 + CD31 + CXCR4 + lymphocytes. These findings demonstrate a clear microvascular perturbation in patients with short disease duration, low disease activity and no CV risk factors.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30608206</pmid><doi>10.1177/0961203318821161</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2019-02, Vol.28 (2), p.210-216 |
| issn | 0961-2033 1477-0962 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2164103349 |
| source | Sage Journals Online |
| subjects | Angiogenesis Cardiovascular diseases CD3 antigen CXCR4 protein Diabetes mellitus Doppler effect Echocardiography Hypercholesterolemia Lupus Lymphocytes Lymphocytes T Microvasculature Peripheral blood Risk factors Smoking Systemic lupus erythematosus |
| title | Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors |
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