Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors

Objective The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematos...

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Bibliographic Details
Published in:Lupus 2019-02, Vol.28 (2), p.210-216
Main Authors: Cavazzana, I, Piantoni, S, Sciatti, E, Fredi, M, Taraborelli, M, Bonadei, I, Airò, P, Metra, M, Tincani, A, Franceschini, F, Vizzardi, E
Format: Article
Language:English
Subjects:
Angiogenesis
Cardiovascular diseases
CD3 antigen
CXCR4 protein
Diabetes mellitus
Doppler effect
Echocardiography
Hypercholesterolemia
Lupus
Lymphocytes
Lymphocytes T
Microvasculature
Peripheral blood
Risk factors
Smoking
Systemic lupus erythematosus
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Summary:Objective The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3 + CD31 + CXCR4 + lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors. Methods Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping. Results SLE ED+ more frequently showed NVC abnormalities compared with HCs (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203318821161