Efficacy and Safety of Deep Sedation in Percutaneous Radiofrequency Ablation for Hepatocellular Carcinoma

Introduction Radiofrequency ablation (RFA) has been accepted as safe and effective for treating early-stage hepatocellular carcinoma (HCC). However, it often causes severe pain. Therefore, in this study, we performed RFA under deep sedation and investigated its efficacy and safety. Methods We conduc...

Full description

Saved in:
Bibliographic Details
Published in:Advances in therapy 2019-02, Vol.36 (2), p.344-354
Main Authors: Sato, Koki, Taniki, Nobuhito, Kanazawa, Ryo, Shimizu, Motonori, Ishii, Shigeto, Ohama, Hideko, Takawa, Masashi, Nagamatsu, Hiroaki, Imai, Yasuharu, Shiina, Shuichiro
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - therapy
Cardiology
Catheter Ablation - adverse effects
Catheter Ablation - methods
Deep Sedation - methods
Endocrinology
Female
Health technology assessment
Humans
Internal Medicine
Liver Neoplasms - surgery
Liver Neoplasms - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Oncology
Original Research
Pain, Procedural - therapy
Pharmacology/Toxicology
Retrospective Studies
Rheumatology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Radiofrequency ablation (RFA) has been accepted as safe and effective for treating early-stage hepatocellular carcinoma (HCC). However, it often causes severe pain. Therefore, in this study, we performed RFA under deep sedation and investigated its efficacy and safety. Methods We conducted a retrospective study including 511 HCC patients who received approximately 886 RFA treatments between December 2014 and November 2016 at our institution. Respiratory depression was defined as oxygen saturation of below 90%; and severe body movement was defined as movement caused by pain, which was managed by lowering the power of the generator. Factors associated with respiratory depression and severe body movement were examined via univariate and multivariate regression analyses. Results Respiratory depression occurred in 15.3% of the patients and severe body movement in 26.5% of the patients. In the multivariate analysis, BMI (≥ 25 kg/m 2 , odds ratio [OR] = 1.75, P  = 0.035) and longer ablation (≥ 10 min, OR = 2.59, P  = 0.002) were significant respiratory depression-related factors. Male sex (OR = 2.02, P  = 0.005), Child–Pugh class A (odds ratio = 1.96, P  = 0.018), and longer ablation (≥ 10 min, OR = 3.03, P  
ISSN:0741-238X
1865-8652
DOI:10.1007/s12325-018-0865-z