Potential role of orbitofrontal surface morphology on social and cognitive functions in high-risk subjects for psychosis and schizophrenia patients

•This MRI study examined orbitofrontal cortex (OFC) morphology in psychosis.•High-risk subjects shared an altered OFC morphology with schizophrenia patients.•OFC morphology was related to social and cognitive functions in schizophrenia.•Neural underdevelopment of OFC may be related to vulnerability...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2019-01, Vol.283, p.92-95
Main Authors: Takahashi, Tsutomu, Nakamura, Mihoko, Nishikawa, Yumiko, Komori, Yuko, Nishiyama, Shimako, Takayanagi, Yoichiro, Furuichi, Atsushi, Kido, Mikio, Sasabayashi, Daiki, Higuchi, Yuko, Noguchi, Kyo, Suzuki, Michio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cognition
Cognition - physiology
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging - methods
Male
Orbitofrontal cortex
Prefrontal Cortex - diagnostic imaging
Prospective Studies
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - psychology
Risk Factors
Schizophrenia - diagnostic imaging
Schizophrenic Psychology
Social Behavior
Social function
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•This MRI study examined orbitofrontal cortex (OFC) morphology in psychosis.•High-risk subjects shared an altered OFC morphology with schizophrenia patients.•OFC morphology was related to social and cognitive functions in schizophrenia.•Neural underdevelopment of OFC may be related to vulnerability to psychosis. This MRI study examined the surface morphology of the orbitofrontal cortex (OFC) and its relation to social and cognitive functions in 38 individuals with at-risk mental state (ARMS) and 63 schizophrenia patients in comparison with 61 healthy controls. The ARMS and schizophrenia groups had increased right OFC Type III expression and fewer orbital sulci, which were partly associated with social and cognitive impairments. OFC underdevelopment may underlie vulnerability to psychosis, as well as the core clinical features of the illness.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2018.12.002