Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications

[Display omitted] Electrospun nanofibrous dressings present suitable characteristics to be used in wound healing, such as high porosity and high surface area-to-volume ratio. In this study, a wound dressing based on PLGA and Aloe vera containing lipid nanoparticles (NLCs) was developed. NLCs were ad...

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Bibliographic Details
Published in:International journal of pharmaceutics 2019-02, Vol.556, p.320-329
Main Authors: Garcia-Orue, Itxaso, Gainza, Garazi, Garcia-Garcia, Patricia, Gutierrez, Francisco Borja, Aguirre, Jose Javier, Hernandez, Rosa Maria, Delgado, Araceli, Igartua, Manoli
Format: Article
Language:English
Subjects:
Aloe vera
Db/db mice
Electrospinning
Lipid nanoparticles
PLGA
Wound healing
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Summary:[Display omitted] Electrospun nanofibrous dressings present suitable characteristics to be used in wound healing, such as high porosity and high surface area-to-volume ratio. In this study, a wound dressing based on PLGA and Aloe vera containing lipid nanoparticles (NLCs) was developed. NLCs were added in order to add a lipid component that could avoid the adhesion of the dressing to the wound and improve its handling. Membranes with and without NLCs were composed of uniform fibers of about 1 µm in diameter. Their porosity was above 80% and their thickness was about 160 µm. Both dressings showed similar water vapour transmission rate 1100 g/m2day. The formulation containing NLCs presented a higher ultimate tensile strength (2.61 ± 0.46 MPa) and a higher water uptake. Both formulations were biocompatible in vitro. Furthermore, the cell adhesion assay demonstrated that both membranes had a low adherence profile, although it was lower with the dressing containing NLCs. Finally, their efficacy was evaluated in a full thickness wound healing assay conducted in db/db mice, where both enhanced healing similarly. Accordingly, the PLGA-AV-NLC membrane might be a promising strategy for the treatment of chronic wounds, since it improved handling in comparison to the formulation without NLCs.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2018.12.010