Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3

Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of d -glucose in the β-cells. The present study...

Full description

Saved in:
Bibliographic Details
Published in:Pflügers Archiv 2019-04, Vol.471 (4), p.647-654
Main Authors: Sanchez-Andres, Juan V., Malaisse, Willy J., Kojima, Itaru
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Electrophysiological Phenomena - physiology
Electrophysiology
Glucose
Glucose - metabolism
Hexose
Human Physiology
Insulin
Insulin - metabolism
Insulin Secretion - physiology
Insulin-Secreting Cells - metabolism
Insulin-Secreting Cells - physiology
Islets of Langerhans - metabolism
Islets of Langerhans - physiology
Mice
Molecular Medicine
Neurosciences
Pancreas
Receptors
Signaling and Cell Physiology
Sucralose
Sweet taste
Taste
Taste - physiology
Taste Buds - metabolism
Taste Buds - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of d -glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose was inefficient in the absence of d -glucose, but induced on occasion electrical activity in mouse β-cells exposed to low non-stimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of d -glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon pancreatic β-cell bioelectrical activity.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-018-2237-6