Chronic social defeat stress-induced enhancement of T-type calcium channels increases burst-firing neurons in the ventral subiculum

The ventral subiculum (vSub), a representative output structure of the hippocampus, serves as a main limbic region in mediating the brain's response to stress. There are three subtypes of subicular pyramidal neurons based on their firing patterns: regular-spiking (RS), weak-bursting (WB) and st...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2019-01, Vol.508 (4), p.1182-1187
Main Authors: Lee, Soonje, Lee, Changwoo, Woo, Changsu, Kang, Shin Jung, Shin, Ki Soon
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Burst firing
Calcium Channel Blockers - pharmacology
Calcium Channels, T-Type - metabolism
Cav3.1
Chronic Disease
Hippocampus - drug effects
Hippocampus - physiopathology
Male
Mice, Inbred C57BL
Neurons - drug effects
Neurons - physiology
Social Behavior
Social defeat stress
Stress, Psychological - metabolism
Stress, Psychological - physiopathology
T-type calcium channels
Ventral subiculum
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Summary:The ventral subiculum (vSub), a representative output structure of the hippocampus, serves as a main limbic region in mediating the brain's response to stress. There are three subtypes of subicular pyramidal neurons based on their firing patterns: regular-spiking (RS), weak-bursting (WB) and strong-bursting (SB) neurons, located differently along proximal–distal axis. Here, we found that chronic social defeat stress (CSDS) in mice increased the population of SB neurons but decreased RS neurons in the proximal vSub. Specific blockers of T-type calcium channels inhibited the burst firings with a concomitant reduction of afterdepolarization, suggesting that T-type calcium channels underlie the burst-spiking activity. Consistently, CSDS increased both T-type calcium currents and expression of Cav3.1 proteins, a subtype of T-type calcium channels, in the proximal vSub. Therefore, we conclude that CSDS-induced enhancement of Cav3.1 expression increased bursting neuronal population in the vSub, which may contribute to stress-related behaviors. •Chronic social defeat stress increased the population of burst-spiking neurons in the proximal ventral subiculum.•Burst firing and afterdepolarization were inhibited by selective T-type calcium channel blockers.•Chronic social defeat stress increased T-type calcium currents and the expression of Cav3.1 channels.•Chronic social defeat stress-induced increase of burst-spiking neurons is mediated by Cav3.1 channels.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2018.12.073