Prevalence of hepatitis C virus infection and its impact on the prognosis of head and neck cancer patients

•HCV infection was more prevalent in head and neck cancer (HNC) patients.•HCV infection is associated with an increased risk of HNC.•HCV infection does not worsens the prognosis of HNC patients. Several studies have shown a higher prevalence of hepatitis C virus (HCV) infection among patients with h...

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Bibliographic Details
Published in:Oral oncology 2018-12, Vol.87, p.138-143
Main Authors: Rangel, Juliana de Brito, Thuler, Luiz Claudio Santos, Pinto, Jorge Francisco da Cunha
Format: Article
Language:English
Subjects:
Adult
Aged
Brazil - epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Head and neck cancer
Head and Neck Neoplasms - blood
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - mortality
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C Antibodies - blood
Hepatitis C Antibodies - isolation & purification
Hepatitis C virus
Humans
Male
Middle Aged
Neoplasms, Second Primary - blood
Neoplasms, Second Primary - epidemiology
Overall survival
Prevalence
Prognosis
Retrospective Studies
Risk Factors
Serologic Tests
Squamous Cell Carcinoma of Head and Neck - blood
Squamous Cell Carcinoma of Head and Neck - etiology
Squamous Cell Carcinoma of Head and Neck - mortality
Survival Analysis
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Summary:•HCV infection was more prevalent in head and neck cancer (HNC) patients.•HCV infection is associated with an increased risk of HNC.•HCV infection does not worsens the prognosis of HNC patients. Several studies have shown a higher prevalence of hepatitis C virus (HCV) infection among patients with head and neck cancer (HNC) compared to the general population. In Brazil, the prevalence of HCV infection is considered low (1.38%). The aim of this study was to determine HCV prevalence and how this can modify outcomes of patients with HNC. Retrospective cohort. Patients with a diagnosis of malignant neoplasm in the head and neck (HN) region and who had serology performed for HCV were included. Patients were classified into two groups: head and neck squamous cell carcinoma (HNSCC) and other head and neck malignant neoplasms (OHNMN). Descriptive statistics were performed for all variables of interest. Means were compared using ANOVA and proportions using chi-square tests. Survival data were compared by Kaplan-Meier curves and log-rank test. Global HCV prevalence in patients with HNC was 7.8%, reaching 12.8% in HNSCC and 3.4% in OHNMN (p = 0.003). There was a higher risk of developing a second primary neoplasm in HNSCC compared to OHNMN patients (20.6% versus 4.6%; p = 0.001). The mean survival was not different between HCV-positive and HCV-negative patients (6.0 years versus 6.6 years, respectively, p = 0.516). The prevalence of HCV infection was higher in HNC patients compared to the general Brazilian population. It seems reasonable to consider that HCV infection is associated with an increased risk of HNC, but HCV infection does not worsens the prognosis of HNC patients.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2018.10.024