Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust

IntroductionClusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).AimWe describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2019-03, Vol.76 (3), p.178-180
Main Authors: Guarnieri, Gabriella, Bizzotto, Rosana, Gottardo, Ottorino, Velo, Emanuela, Cassaro, Mauro, Vio, Stefania, Putzu, Maria Grazia, Rossi, Federica, Zuliani, Paolo, Liviero, Filippo, Mason, Paola, Maestrelli, Piero
Format: Article
Language:English
Subjects:
Abdomen
Alcohol
Artificial stone
Bathrooms
Carbon monoxide
Conglomerates
Crystal structure
Crystallinity
Crystals
Disease
Dust
Exposure
Fabrication
Family physicians
Inhalation
Levels
Light microscopy
Liver
Lungs
Lymphatic system
Medical personnel
Microscopy
Occupational exposure
Occupational hazards
Physicians
Quartz
Respiration
Sarcoidosis
Scanning electron microscopy
SHORT REPORT
Silica
Silicon dioxide
Silicosis
Spectroscopy
Systematic review
Tissues
Toxicity
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Summary:IntroductionClusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).AimWe describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates.MethodsA confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy.ResultsThe development of the disease
ISSN:1351-0711
1470-7926
DOI:10.1136/oemed-2018-105462