A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders

•Evidences for Th17 cells plasticity are reviewed.•Highlights the importance of Th17 cells plasticity in immune diseases.•Th1-like Th17 cells play pivotal role in autoimmune disorders. The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different...

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Bibliographic Details
Published in:Molecular immunology 2019-01, Vol.105, p.107-115
Main Authors: Kamali, Ali N., Noorbakhsh, Seyedeh Masoomeh, Hamedifar, Haleh, Jadidi-Niaragh, Farhad, Yazdani, Reza, Bautista, José M., Azizi, Gholamreza
Format: Article
Language:English
Subjects:
Autoimmune disorders
Inflammatory disease
Th1 cells
Th1-like Th17 cells
Th17 cells
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Summary:•Evidences for Th17 cells plasticity are reviewed.•Highlights the importance of Th17 cells plasticity in immune diseases.•Th1-like Th17 cells play pivotal role in autoimmune disorders. The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells co-express retinoic acid-related orphan receptor gamma t (RORγt) and transcription factor T-box-expressed-in-T-cells (T-bet) and produce both interleukin (IL)-17 and interferon (IFN)-γ. Recent reports have shown that Th1-like Th17 cells play crucial roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, as well as, some primary immunodeficiency with autoimmune features. Here, the actual mechanisms for Th17 cells plasticity to Th1-like Th17 cells are discussed and reviewed in association to the role that Th1-like Th17 cells have on inflammatory and autoimmune disorders.
ISSN:0161-5890
1872-9142
DOI:10.1016/j.molimm.2018.11.015