The long intergenic non-protein coding RNA 707 promotes proliferation and metastasis of gastric cancer by interacting with mRNA stabilizing protein HuR

Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progression. The long intergenic non-protein coding RNA 707 (LINC00707), 3087 bp in length, was recently reported to be an essential oncogene in promoting lung adenocarcinoma cell pro...

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Bibliographic Details
Published in:Cancer letters 2019-02, Vol.443, p.67-79
Main Authors: Xie, Min, Ma, Tianshi, Xue, Jiangyang, Ma, Hongwei, Sun, Ming, Zhang, Zhihong, Liu, Minjuan, Liu, Yinghua, Ju, Songwen, Wang, Zhaoxia, De, Wei
Format: Article
Language:English
Subjects:
Adenocarcinoma
Apoptosis
Bioinformatics
Cell culture
Cell growth
Cell proliferation
F11R
Gastric cancer
Gene expression
HuR protein
lncRNA
Lung cancer
Lungs
Lymph nodes
Medical prognosis
Metastases
Metastasis
mRNA stability
Nutrition research
Prognosis
RNA-protein interactions
VAV3
“LINC00707-HuR” coalition
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Summary:Multiple studies have revealed that long non-coding RNAs (lncRNAs) extensively participate in human cancer malignant progression. The long intergenic non-protein coding RNA 707 (LINC00707), 3087 bp in length, was recently reported to be an essential oncogene in promoting lung adenocarcinoma cell proliferation and metastasis. However, its role in gastric cancer (GC) remains unclear. In this study, we identified that LINC00707 was excessively expressed in GC tissues and correlated with advanced stage, larger tumor size, lymph node metastasis and poorer prognosis in GC patients. In vitro and in vivo assays showed that LINC00707 promote GC cell proliferation and metastasis. Mechanistically, LINC00707 could abundantly interact with mRNA stabilizing protein HuR; “LINC00707-HuR” coalition ulteriorly combined with VAV3/F11R mRNAs and increased their stability. Taken together, our findings prove that LINC00707 may act as an oncogene in GC by regulating mRNA stability and serve as a potential target for GC diagnosis and prognosis. •LINC00707 expression is significantly upregulated in human gastric cancer tissues.•LINC00707 overexpression is correlated with gastric cancer malignant progression and poor prognosis.•LINC00707 could promote GC growth and metastasis both in vitro and in vivo.•LINC00707 could abundantly interact with mRNA stabilizing protein HuR.•“LINC00707-HuR” coalition could increase VAV3 and F11R mRNA stability.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2018.11.032